大鼠基底前脑鹅膏蕈氨酸损伤后皮质葡萄糖代谢与血流的解偶联：一项正电子发射断层扫描研究。

Uncoupling between cortical glucose metabolism and blood flow after ibotenate lesion of the rat basal forebrain: a PET study.

作者信息

Ogawa M, Fukuyama H, Ouchi Y, Yamauchi H, Matsuzaki S, Kimura J, Tsukada H

机构信息

Department of Neurology, Faculty of Medicine, Kyoto University, Japan.

出版信息

Neurosci Lett. 1996 Feb 9;204(3):193-6. doi: 10.1016/0304-3940(96)12355-7.

DOI:10.1016/0304-3940(96)12355-7

PMID:8938263

Abstract

We evaluated the cerebral metabolic rate of glucose (CMRGlu) and cerebral blood flow (CBF) after unilateral lesioning of the rat basal forebrain cholinergic projection system using ibotenic acid. Using positron emission tomography, we measured CMRGlu and CBF with [18F]-2-fluoro-2-deoxy-D-glucose (FDG) and with H2(15)O, respectively. Three days after surgery, CMRGlu and k3* (the rate constant for the phosphorylation of FDG) were reduced in the frontal cortex on the ibotenic acid-injected side, whereas CBF and K1* (the rate constant for the FDG transport from the plasma to brain) in the same rats remained in the normal range. It is concluded that the decreased cortical CMRGlu after the lesion of the cholinergic system projecting from the basal forebrain is due to the diminished neural activity rather than to decreased CBF.

摘要

我们使用鹅膏蕈氨酸对大鼠基底前脑胆碱能投射系统进行单侧损伤后，评估了其大脑葡萄糖代谢率（CMRGlu）和脑血流量（CBF）。采用正电子发射断层扫描技术，我们分别用[18F]-2-氟-2-脱氧-D-葡萄糖（FDG）和H2(15)O测量了CMRGlu和CBF。手术后三天，注射鹅膏蕈氨酸一侧的额叶皮质中CMRGlu和k3*（FDG磷酸化的速率常数）降低，而同一批大鼠中的CBF和K1*（FDG从血浆转运至脑内的速率常数）仍处于正常范围。得出的结论是，基底前脑投射的胆碱能系统损伤后皮质CMRGlu降低是由于神经活动减弱而非CBF减少所致。