下一代重组和合成抗癌疫苗。
The next wave of recombinant and synthetic anticancer vaccines.
作者信息
Irvine K R, Restifo N P
机构信息
Surgery Branch, National Cancer Institute, Bethesda, MD 20892, USA.
出版信息
Semin Cancer Biol. 1995 Dec;6(6):337-47. doi: 10.1016/1044-579x(95)90003-9.
Abstract
The identification of tumor-associated antigens (TAA) recognized by T lymphocytes makes the development of antigen-specific synthetic and recombinant vaccines possible. The expression of TAA within a recombinant vector increases control over the kinetics and quantity, the molecular form, and the subcellular location of the immunogen delivered. The next generation of antitumor vaccines employs cytokines and costimulatory molecules expressed in concert with TAA that are capable of augmenting the activation and proliferation of antitumor immune responses. The ultimate goal of these new strategies, the treatment of established cancer, is now being realized in animal models.
摘要
T淋巴细胞所识别的肿瘤相关抗原（TAA）的鉴定使得抗原特异性合成疫苗和重组疫苗的研发成为可能。重组载体内TAA的表达增强了对所递送免疫原的动力学、数量、分子形式及亚细胞定位的控制。新一代抗肿瘤疫苗采用与TAA协同表达的细胞因子和共刺激分子，这些细胞因子和共刺激分子能够增强抗肿瘤免疫反应的激活和增殖。这些新策略的最终目标，即对已确诊癌症的治疗，目前正在动物模型中得以实现。
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