Ahmad A, Hart I R
Richard Dimbleby Department of Cancer Research/ICRF, Rayne Institute, UMDS, St. Thomas' Hospital, London, UK.
J Hematother. 1996 Oct;5(5):525-35. doi: 10.1089/scd.1.1996.5.525.
Metastasis is the major cause of death in cancer patients. Our understanding of the molecular genetic and biologic events that contribute to tumor cell dissemination has increased considerably over the last decade. It is clear that close anatomic and temporal cooperation between cellular adhesion molecules, extracellular matrix-degrading proteases, and tumor vascularization is an essential component of the metastatic behavior of cancer cells. With this improved understanding have come novel antimetastatic therapies targeting distinct molecules and steps in the metastatic cascade. Here, we review the role of matrix-degrading enzymes, changes in cellular adhesive capacity, and tumor angiogenesis during cancer spread.
转移是癌症患者死亡的主要原因。在过去十年中，我们对促成肿瘤细胞播散的分子遗传学和生物学事件的理解有了显著增加。很明显，细胞粘附分子、细胞外基质降解蛋白酶和肿瘤血管生成之间紧密的解剖学和时间上的协同作用是癌细胞转移行为的一个重要组成部分。随着这种理解的加深，出现了针对转移级联中不同分子和步骤的新型抗转移疗法。在这里，我们综述基质降解酶的作用、细胞粘附能力的变化以及癌症扩散过程中的肿瘤血管生成。
