多发性骨髓瘤自体移植中的骨髓瘤干细胞。

Myeloma stem cells in autografting in multiple myeloma.

作者信息

To L B, Horvath N, Dyson P, Henry J, Sykes P, Brisco M, Morley A, Bennetts B

机构信息

Division of Haematology, Hanson Centre for Cancer Research, Adelaide, S. Australia.

出版信息

J Hematother. 1996 Oct;5(5):557-9. doi: 10.1089/scd.1.1996.5.557.

DOI:10.1089/scd.1.1996.5.557

PMID:8938529

Abstract

Autologous transplantation has been used increasingly over the last 10 years for the treatment of multiple myeloma. As is the case in other cancers treated by high-dose therapy and stem cell rescue, the contribution of occult tumor cells in the graft to relapse posttransplant remains to be resolved. In this report, we review the biology and differentiation of plasma cells in the context of their significance as an origin of relapse in multiple myeloma.

摘要

在过去10年中，自体移植越来越多地用于治疗多发性骨髓瘤。与其他接受高剂量疗法和干细胞救援治疗的癌症一样，移植物中隐匿肿瘤细胞对移植后复发的影响仍有待解决。在本报告中，我们在浆细胞作为多发性骨髓瘤复发起源的重要性背景下，综述了浆细胞的生物学特性和分化情况。