肾上腺髓质素对大鼠系膜细胞有丝分裂的抑制作用。

Inhibitory effect of adrenomedullin on rat mesangial cell mitogenesis.

作者信息

Segawa K, Minami K, Sata T, Kuroiwa A, Shigematsu A

机构信息

2nd Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

出版信息

Nephron. 1996;74(3):577-9. doi: 10.1159/000189455.

DOI:10.1159/000189455

PMID:8938684

Abstract

We investigated the effects of adrenomedullin on rat mesangial cell proliferation. Adrenomedullin (10(-10)-10(-7) M inhibited both [3H]thymidine incorporation into cultured rat mesangial cells and cell proliferation in a concentration-dependent manner. Adrenomedullin (10(-10)-10(-6) M) stimulated cyclic adenosine monophosphate accumulation in rat mesangial cells in a concentration-dependent manner. These findings suggest that adrenomedullin inhibits proliferation of rat mesangial cells probably through a cyclic adenosine monophosphate-dependent mechanism.

摘要

我们研究了肾上腺髓质素对大鼠系膜细胞增殖的影响。肾上腺髓质素（10⁻¹⁰ - 10⁻⁷ M）以浓度依赖的方式抑制[³H]胸腺嘧啶核苷掺入培养的大鼠系膜细胞以及细胞增殖。肾上腺髓质素（10⁻¹⁰ - 10⁻⁶ M）以浓度依赖的方式刺激大鼠系膜细胞中环磷酸腺苷的积累。这些发现表明，肾上腺髓质素可能通过环磷酸腺苷依赖性机制抑制大鼠系膜细胞的增殖。