Golstein M A, Steinfeld S
Rheumatology Department, Caesar De Paepe Hospital Center, Brussels, Belgium.
Rev Rhum Engl Ed. 1996 Oct;63(9):624-8.
Chronic eosinophilic pneumonia and Churg-Strauss syndrome are two uncommon conditions of unknown etiology that share similar pulmonary manifestations. Whereas chronic eosinophilic pneumonia mainly targets the lung, Churg-Strauss syndrome is a systemic diseases. We report three patients who developed Churg-Strauss syndrome about eight years after being diagnosed with chronic eosinophilic pneumonia. Hypereosinophilia and high IgE levels were present in both conditions. Elevation of IgA levels was consistently demonstrated at the time of the diagnosis of Churg-Strauss syndrome. IgA elevation may be useful as a marker for progression of chronic eosinophilic pneumonia to Churg-Strauss syndrome.
慢性嗜酸性粒细胞性肺炎和变应性肉芽肿性血管炎是两种病因不明的罕见疾病，具有相似的肺部表现。慢性嗜酸性粒细胞性肺炎主要累及肺部，而变应性肉芽肿性血管炎是一种全身性疾病。我们报告了3例在被诊断为慢性嗜酸性粒细胞性肺炎约8年后发生变应性肉芽肿性血管炎的患者。两种疾病均存在嗜酸性粒细胞增多和高IgE水平。在变应性肉芽肿性血管炎诊断时，IgA水平持续升高。IgA升高可能作为慢性嗜酸性粒细胞性肺炎进展为变应性肉芽肿性血管炎的一个标志物。
