Young R F
Northwest Hospital Gamma Knife Center, Seattle, Wash., USA.
Stereotact Funct Neurosurg. 1996;66(1-3):19-23. doi: 10.1159/000099662.
Sixty patients underwent a total of 64 separate Gamma Knife radiosurgical procedures for treatment of a variety of functional disorders between July 1992 and February 1995. Thirty-four patients with intractable pain received unilateral (32 patients) or bilateral (2 patients) lesions in the intralaminar thalamus. Twenty-nine patients with facial pain, including 19 with typical trigeminal neuralgia. 8 with facial pain due to tumors involving the trigeminal nerve and 2 with other forms of facial pain, were also treated. Five patients with Parkinson's disease underwent pallidotomy (2) or thalamotomy (3) with the Gamma Knife and 2 patients with non-Parkinson's tremor were also treated with gamma-thalamotomy. The rate of improvement or resolution of the functional disorders was similar to that seen with other forms of surgical therapy. No immediate complications were seen, but 4 patients who underwent thalamotomy for pain developed delayed transient complications and 1 death was seen following bilateral thalamotomy.
1992年7月至1995年2月期间，60例患者共接受了64次伽玛刀放射外科手术，以治疗各种功能性疾病。34例顽固性疼痛患者在丘脑板内核接受了单侧（32例患者）或双侧（2例患者）毁损。29例面部疼痛患者也接受了治疗，其中包括19例典型三叉神经痛患者、8例因肿瘤累及三叉神经导致面部疼痛的患者以及2例其他形式面部疼痛的患者。5例帕金森病患者接受了伽玛刀苍白球切开术（2例）或丘脑切开术（3例），2例非帕金森震颤患者也接受了伽玛丘脑切开术。功能性疾病的改善或缓解率与其他形式的手术治疗相似。未见即刻并发症，但4例因疼痛接受丘脑切开术的患者出现了延迟性短暂并发症，双侧丘脑切开术后有1例死亡。
