Higashiyama M, Doi O, Kodama K, Yokouchi H, Tateishi R
Department of Thoracic Surgery, Center for Adult Diseases, Osaka, Japan.
Tumour Biol. 1996;17(6):341-4. doi: 10.1159/000217998.
Immunohistochemical analysis of Bcl-2 oncoprotein, one of the oncogenes associated with the regulation of programmed cell death, was performed on 12 surgically resected tumors of the combined type of small-cell lung cancer. Ten cases (83%) expressed Bcl-2 oncoprotein within the tumor tissues. Two of them showed its expression in both the small cell carcinoma and non-small cell carcinoma types, and 7 cases exhibited Bcl-2 expression only in the portion of the small cell carcinoma. Considering previous reports indicating a high prevalence of Bcl-2 oncoprotein expression in small cell lung cancer, it is suggested that Bcl-2 oncoprotein even in the combined type of lung cancer may play an important role in tumorigenesis and tumor development and ensuing histological alterations between small cell carcinoma and non-small cell carcinoma types.
对12例手术切除的混合型小细胞肺癌肿瘤进行了免疫组织化学分析，检测与程序性细胞死亡调控相关的癌基因之一Bcl-2癌蛋白。10例（83%）肿瘤组织中表达Bcl-2癌蛋白。其中2例在小细胞癌和非小细胞癌类型中均显示其表达，7例仅在小细胞癌部分表现出Bcl-2表达。鉴于先前报道表明小细胞肺癌中Bcl-2癌蛋白表达的高发生率，提示即使在混合型肺癌中，Bcl-2癌蛋白可能在肿瘤发生、肿瘤发展以及随之而来的小细胞癌和非小细胞癌类型之间的组织学改变中发挥重要作用。
