Pfleiderer B, Campbell T, Hulka C A, Kopans D B, Lean C L, Ackerman J L, Brady T J, Garrido L
Department of Radiology, Massachusetts General Hospital, Charlestown 02129, USA.
Radiology. 1996 Dec;201(3):777-83. doi: 10.1148/radiology.201.3.8939231.
To evaluate, at hydrogen-1 magnetic resonance (MR) spectroscopy, the effect of implantation time, implant status, and implant removal on the amount of silicone in the liver in women with silicone gel-filled breast prostheses.
The study population included 55 women (39 patients with silicone gel-filled prostheses and seven from whom implants had been removed, and nine control subjects [eight with no implant and one with saline-filled implants]). Stimulated-echo acquisition mode, or STEAM, H-1 MR spectroscopy was performed to determine the concentration of silicone in the liver. Implant status at the time of spectroscopy was diagnosed at MR imaging.
Twenty of 39 (51%) women with implants had ruptured prostheses. Resonances associated with the presence of silicone and partially hydrolyzed silicone (0.3 to -0.8 ppm with respect to water at 4.7 ppm) and other resonances that are not yet assigned (-2 to -5 ppm) were detected in 27 (69%) of the 39 women (17 with ruptured implants). Relative signal intensities of the silicone species detected in the liver in these women were found to vary substantially and were not correlated with the status of the implants (P > .70). Silicone resonances were not detected in the livers in the nine control subjects. After implant removal, no resonances between 0.3 and -0.8 ppm were observed in six of seven women, but silicone-related peaks were still detectable in the region of -2 to -5 ppm.
Proton MR spectra obtained in the liver of women with silicone gel-filled breast implants helped measure silicone exposure.
采用氢-1磁共振（MR）波谱法评估硅胶填充乳房假体女性的植入时间、植入状态及取出植入物对肝脏中硅胶含量的影响。
研究对象包括55名女性（39名硅胶填充假体患者、7名已取出植入物者以及9名对照受试者[8名无植入物者和1名盐水填充植入物者]）。采用刺激回波采集模式（STEAM）进行氢-1 MR波谱分析，以测定肝脏中硅胶的浓度。在MR成像时诊断波谱分析时的植入状态。
39名植入假体的女性中有20名（51%）假体破裂。在39名女性中的27名（69%）（17名假体破裂者）检测到与硅胶及部分水解硅胶存在相关的共振（相对于4.7 ppm水为0.3至-0.8 ppm）以及其他尚未确定的共振（-2至-5 ppm）。发现这些女性肝脏中检测到的硅胶种类的相对信号强度差异很大，且与植入物状态无关（P>.70）。9名对照受试者的肝脏中未检测到硅胶共振。取出植入物后，7名女性中有6名在0.3至-0.8 ppm之间未观察到共振，但在-2至-5 ppm区域仍可检测到与硅胶相关的峰。
硅胶填充乳房植入物女性肝脏中获得的质子MR波谱有助于测量硅胶暴露情况。
