Huang H V
Department of Molecular Microbiology, Washington University School of Medicine, Box 8230, 660 South Euclid Avenue, St. Louis, MO 63110-1093, USA.
Curr Opin Biotechnol. 1996 Oct;7(5):531-5. doi: 10.1016/s0958-1669(96)80057-7.
Sindbis virus and other alphavirus gene expression vectors have recently been used to express and study the functions of proteins and RNA, to evaluate classical vaccine and novel antiviral approaches, and for nucleic acid immunization. The vectors will likely attract continuing, innovative applications that exploit their useful features: rapid and efficient gene expression, wide host range, and RNA genomes.
辛德毕斯病毒和其他甲病毒基因表达载体最近已被用于表达和研究蛋白质及RNA的功能,评估传统疫苗和新型抗病毒方法,以及用于核酸免疫。这些载体可能会吸引持续的、创新性的应用,这些应用将利用它们的有用特性:快速高效的基因表达、广泛的宿主范围和RNA基因组。