探寻蛋白质的功能。

Threading your way to protein function.

作者信息

Firestine S M, Nixon A E, Benkovic S J

机构信息

The Pennsylvania State University, Department of Chemistry, 152 Davey Laboratory, University Park, PA 16802, USA.

出版信息

Chem Biol. 1996 Oct;3(10):779-83. doi: 10.1016/s1074-5521(96)90061-7.

DOI:10.1016/s1074-5521(96)90061-7

PMID:8939694

Abstract

It is still very difficult to determine the function of a protein from its sequence. One potential solution to the problem combines the concept of enzyme superfamilies with modern methods of protein structure prediction. Active-site templates can be used as search tools to identify new members of the superfamilies.

摘要

从蛋白质序列确定其功能仍然非常困难。解决这个问题的一种潜在方法是将酶超家族的概念与现代蛋白质结构预测方法相结合。活性位点模板可以用作搜索工具来识别超家族的新成员。