终点：细胞周期蛋白依赖性激酶抑制剂的蛋白水解降解
End of the line: proteolytic degradation of cyclin-dependent kinase inhibitors.
作者信息
Sheaff R J, Roberts J M
机构信息
Department of Basic Sciences, Fred Hutchinson Cancer Research Center, 1124 Columbia Street, Seattle, WA 98104, USA.
出版信息
Chem Biol. 1996 Nov;3(11):869-73. doi: 10.1016/s1074-5521(96)90174-x.
PMID:8939714
Abstract
Cyclin-dependent kinase inhibitors (CKIs) are crucial regulators of cell-cycle progression. The CKI Sic1 controls the timing of DNA replication by inhibiting Clb-Cdc28 kinase. Phosphorylation of Sic1 by CIn-Cdc28 kinase alleviates this inhibition by targeting Sic1 for degradation through the ubiquitin-mediated proteolytic pathway.
摘要
细胞周期蛋白依赖性激酶抑制剂（CKIs）是细胞周期进程的关键调节因子。CKI Sic1通过抑制Clb-Cdc28激酶来控制DNA复制的时间。CIn-Cdc28激酶对Sic1的磷酸化作用通过泛素介导的蛋白水解途径将Sic1靶向降解，从而减轻这种抑制作用。
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