Orkin S H
Howard Hughes Medical Institute, Division of Hematology, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Curr Opin Genet Dev. 1996 Oct;6(5):597-602. doi: 10.1016/s0959-437x(96)80089-x.
Significant advances have been made in the past year in understanding hematopoietic development. Recent studies have clarified the origin and migration of stem cells in early embryos, established potential roles for homeodomain proteins in controlling the proliferation of progenitor cells and in patterning ventral mesoderm, and demonstrated the effects of nuclear proteins on lineage programming and apoptosis.
在过去一年里，造血发育研究取得了重大进展。最近的研究阐明了早期胚胎中干细胞的起源和迁移，确定了同源结构域蛋白在控制祖细胞增殖和腹侧中胚层模式形成中的潜在作用，并证明了核蛋白对谱系编程和细胞凋亡的影响。
