Watanabe S, Arai K i
Department of Molecular and Development Biology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan.
Curr Opin Genet Dev. 1996 Oct;6(5):587-96. doi: 10.1016/s0959-437x(96)80088-8.
JAK-STAT signaling pathways are known to play an essential role in the specific activation of interferon-inducible genes. Many cytokines interacting with the cytokine receptor superfamily also appear to activate these pathways. Recent evidence indicates that JAKs play an essential role(s) in cytokine receptor signaling, including both specific pathways linked to STATs and general pathways regulating cell growth and functions.
已知JAK-STAT信号通路在干扰素诱导基因的特异性激活中起关键作用。许多与细胞因子受体超家族相互作用的细胞因子似乎也能激活这些通路。最近的证据表明，JAK在细胞因子受体信号传导中起关键作用，包括与STAT相关的特定通路以及调节细胞生长和功能的一般通路。
