Piggot P J
Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia. Pennsylvania 19140, USA.
Curr Opin Genet Dev. 1996 Oct;6(5):531-7. doi: 10.1016/s0959-437x(96)80080-3.
Cell-cell and starvation signals are funneled through the phosphorelay to initiate sporulation by activating the transcription regulator SpoOA. Activation of SpoOA leads to synthesis of the transcription factors sigmaF and sigmaE. Substantial advances have been made in our understanding of the signal circuitry of the phosphorelay and of the cell-type-specific activation of the sigma factors.
细胞间信号和饥饿信号通过磷酸化信号转导途径汇聚，激活转录调节因子SpoOA以启动孢子形成。SpoOA的激活导致转录因子sigmaF和sigmaE的合成。我们对磷酸化信号转导途径的信号回路以及sigma因子的细胞类型特异性激活的理解取得了重大进展。
