Lufkin T
Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029-6574, USA.
Curr Opin Genet Dev. 1996 Oct;6(5):575-80. doi: 10.1016/s0959-437x(96)80086-4.
The identification, in transgenic mice, of Hox gene DNA regulatory elements that can recapitulate certain aspects of the endogenous gene expression pattern has proceeded with great success. Perfect reproduction of the correct expression pattern, however, is uncommon, even when large genomic fragments spanning neighboring genes are analyzed, suggesting that important regulatory regions may be located at large distances from the genes they control or that their specific context may be important. Four classes of transcriptional regulators have been identified recently that have been shown to directly regulate Hox gene expression in the murine nervous system: retinoic acid receptors, Krox20, the Pbx/exd family, and the Hox genes themselves.
在转基因小鼠中，对能够重现内源基因表达模式某些方面的Hox基因DNA调控元件的鉴定已取得了巨大成功。然而，即使分析跨越相邻基因的大片段基因组，正确表达模式的完美重现也并不常见，这表明重要的调控区域可能位于与其所控制基因相距甚远的位置，或者其特定背景可能很重要。最近已鉴定出四类转录调节因子，它们已被证明可直接调节小鼠神经系统中的Hox基因表达：视黄酸受体、Krox20、Pbx/exd家族以及Hox基因本身。
