用于人类免疫缺陷病毒1型和猿猴免疫缺陷病毒的口服脊髓灰质炎减毒活疫苗单价池分析
Analysis of live, oral poliovirus vaccine monopools for human immunodeficiency virus type 1 and simian immunodeficiency virus.
作者信息
Khan A S, Shahabuddin M, Bryan T, Joshi B H, Lee S, Hewlett I K
机构信息
Laboratory of Retrovirus Research, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland, USA.
出版信息
J Infect Dis. 1996 Dec;174(6):1185-90. doi: 10.1093/infdis/174.6.1185.
Although there is no evidence for transmission of mammalian retroviruses to humans via vaccine immunization, the allegations of contamination of oral poliovirus vaccines with human immunodeficiency virus (HIV) type 1 or a hypothetical progenitor virus from monkeys has created controversy and dispute regarding the origin of AIDS in humans. Twelve monovalent lots of live, attenuated oral poliovirus vaccine types 1, 2, and 3, which were released for use by a North American manufacturer between 1976-1989, were tested for the presence of HIV-1 and simian immunodeficiency virus (SIV). HIV/SIV were not detected in these monovalent poliovirus vaccine lots with the reverse transcriptase assay, a general detection assay, and highly sensitive and specific polymerase chain reaction assays.
虽然没有证据表明哺乳动物逆转录病毒可通过疫苗免疫传播给人类，但关于口服脊髓灰质炎疫苗被1型人类免疫缺陷病毒（HIV）或一种假设的猴源始祖病毒污染的指控，引发了关于人类艾滋病起源的争议和争论。对1976年至1989年间由一家北美制造商放行使用的12批单价1型、2型和3型口服减毒活脊髓灰质炎疫苗进行了HIV-1和猴免疫缺陷病毒（SIV）检测。通过逆转录酶检测、一种通用检测方法以及高灵敏度和特异性的聚合酶链反应检测，在这些单价脊髓灰质炎病毒疫苗批次中未检测到HIV/SIV。
Zotero 插件