Ohta M, Kuwahara O, Yasumitsu T, Kotake Y, Maeda M, Katsura H, Nakahara K, Kishima H
National Toneyama Hospital for Chest Disease, Osaka, Japan.
Nihon Kyobu Geka Gakkai Zasshi. 1996 Oct;44(10):1847-52.
The discriminant function (Z) for predicting postoperative performance status in patients with giant bulla was addressed in our previous paper. In the present study, patients with dyspnea were classified into Group 1 or Group 2 based on preoperative function, Group 1 showing continuous improvement in dyspnea and Group 2 unchanged or worsened condition after bullectomy. Of the 47 patients in this study, 28 had dyspnea of grade 2 or more, 19 revealing no symptoms prebullectomy. The group predictions for the 28 patients were compared with the postoperative status in dyspnea for over four years following surgery. The predicted grouping in 26 of the 28 (93%) agreed with the postoperative status but in two it did not: one was familial bullous emphysema the other had repeated episodes of pneumonia, both of which were predicted for Group 1. All 19 patients without preoperative dyspnea were studied their symptoms and lung functions before and after bullectomy. After surgery, none showed dyspnea and significant changes of functions. As to preoperative pulmonary function, patients with FEV1.0% of more than 60% and delta N2 of less than 2% were improved, the prediction agreeing with the actual results. Fourteen patients with FEV1.0% of less than 55% showed high delta N2. When delta N2 exceeded 3.5%, deterioration of dyspnea was observed following surgery. Bullectomy is indicated in patients with low pulmonary function, by preoperative FEV1.0% and delta N2.
我们之前的论文探讨了预测巨大肺大疱患者术后功能状态的判别函数(Z)。在本研究中,根据术前功能将呼吸困难患者分为1组或2组,1组患者术后呼吸困难持续改善,2组患者在肺大疱切除术后病情未改善或恶化。本研究的47例患者中,28例有2级或更严重的呼吸困难,19例在肺大疱切除术前无任何症状。将这28例患者的分组预测结果与术后四年多的呼吸困难状态进行比较。28例患者中有26例(93%)的预测分组与术后状态相符,但有2例不符:1例为家族性肺气肿,另1例有反复肺炎发作,这2例患者均被预测为1组。对所有19例术前无呼吸困难的患者在肺大疱切除术前、后的症状和肺功能进行了研究。术后,所有患者均未出现呼吸困难,功能也无明显变化。对于术前肺功能,FEV1.0%超过60%且氮洗出率增量(delta N2)小于2%的患者术后得到改善,预测结果与实际结果相符。14例FEV1.0%小于55%的患者氮洗出率增量较高。当氮洗出率增量超过3.5%时,术后观察到呼吸困难恶化。根据术前FEV1.0%和氮洗出率增量,肺功能低下的患者适合进行肺大疱切除术。