一种新型血红素蛋白，在深红红螺菌中作为一氧化碳依赖性转录激活因子发挥作用。
A novel heme protein that acts as a carbon monoxide-dependent transcriptional activator in Rhodospirillum rubrum.
作者信息
Aono S, Nakajima H, Saito K, Okada M
机构信息
School of Materials Science, Japan Advanced Institute of Science and Technology, Ishikawa, Japan.
出版信息
Biochem Biophys Res Commun. 1996 Nov 21;228(3):752-6. doi: 10.1006/bbrc.1996.1727.
The gene coding for a carbon monoxide-dependent transcriptional activator (cooA) in Rhodospirillum rubrum has been expressed in E. coli, and the recombinant CooA has been purified. CooA contains b-type heme which may act as a CO sensor in vivo. CO-bound CooA was formed when reduced CooA was reacted with CO, but not in the case of oxidized CooA. CooA is the first example of the heme protein acting as a DNA-binding transcriptional activator.
编码深红红螺菌中一氧化碳依赖性转录激活因子（CooA）的基因已在大肠杆菌中表达，并且重组CooA已被纯化。CooA含有b型血红素，其在体内可能充当一氧化碳传感器。当还原型CooA与一氧化碳反应时会形成一氧化碳结合的CooA，但氧化型CooA则不会。CooA是血红素蛋白作为DNA结合转录激活因子的首个实例。
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