使用GBR 12909的长效酯衍生物1-[2-[双(4-氟苯基)甲氧基]乙基]-4-(3-羟基-3-苯基丙基)哌嗪基癸酸酯，恒河猴对可卡因维持反应持续减少。 - Suppr

Suppr

超能文献

Sustained decrease in cocaine-maintained responding in rhesus monkeys with 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-hydroxy-3-phenylpropyl) piperazinyl decanoate, a long-acting ester derivative of GBR 12909.

作者信息

Glowa J R, Fantegrossi W E, Lewis D B, Matecka D, Rice K C, Rothman R B

机构信息

Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA.

出版信息

J Med Chem. 1996 Nov 22;39(24):4689-91. doi: 10.1021/jm960551t.

DOI:10.1021/jm960551t

PMID:8941381

Abstract

摘要

相似文献

Sustained decrease in cocaine-maintained responding in rhesus monkeys with 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-hydroxy-3-phenylpropyl) piperazinyl decanoate, a long-acting ester derivative of GBR 12909.使用GBR 12909的长效酯衍生物1-[2-[双(4-氟苯基)甲氧基]乙基]-4-(3-羟基-3-苯基丙基)哌嗪基癸酸酯，恒河猴对可卡因维持反应持续减少。

J Med Chem. 1996 Nov 22;39(24):4689-91. doi: 10.1021/jm960551t.

Oxygenated analogues of 1-[2-(Diphenylmethoxy)ethyl]- and 1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as potential extended-action cocaine-abuse therapeutic agents.1-[2-(二苯基甲氧基)乙基]-和1-[2-[双(4-氟苯基)甲氧基]乙基]-4-(3-苯基丙基)哌嗪（GBR 12935和GBR 12909）的氧化类似物作为潜在的长效可卡因滥用治疗剂。

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Heteroaromatic analogs of 1-[2-(diphenylmethoxy)ethyl]- and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as high-affinity dopamine reuptake inhibitors.1-[2-(二苯基甲氧基)乙基]-和1-[2-[双(4-氟苯基)甲氧基]乙基]-4-(3-苯基丙基)哌嗪（GBR 12935和GBR 12909）的杂芳族类似物作为高亲和力多巴胺再摄取抑制剂。

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Development of long-acting dopamine transporter ligands as potential cocaine-abuse therapeutic agents: chiral hydroxyl-containing derivatives of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine.长效多巴胺转运体配体作为潜在可卡因滥用治疗药物的研发：1-[2-[双(4-氟苯基)甲氧基]乙基]-4-(3-苯基丙基)哌嗪和1-[2-(二苯基甲氧基)乙基]-4-(3-苯基丙基)哌嗪的含手性羟基衍生物

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Effects of phentermine on responding maintained under multiple fixed-ratio schedules of food and cocaine presentation in the rhesus monkey.苯丁胺对恒河猴在食物和可卡因呈现的多种固定比率时间表下维持反应的影响。

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Relationship between in vivo occupancy at the dopamine transporter and behavioral effects of cocaine, GBR 12909 [1-{2-[bis-(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine], and benztropine analogs.多巴胺转运体的体内占有率与可卡因、GBR 12909 [1-{2-[双-(4-氟苯基)甲氧基]乙基}-4-(3-苯基丙基)哌嗪]及苯托品类似物的行为效应之间的关系。

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