Singhai A K, Jain S, Jain N K
Department of Pharmaceutical Sciences, University of Saugar, India.
Pharmazie. 1996 Oct;51(10):737-40.
Ketoprofen (1) an analgesic, antipyretic and anti-inflammatory agent, is practically insoluble in water. An increase in the aqueous solubility of 1 was attempted by various cosolvents. The solubility increased up to 8556 times (maximum) in case of ethanol while it was 33 times (minimum) in case of glycerol. Using selected cosolvents and hydrotropes, aqueous injections of 1 were formulated.
酮洛芬（1）是一种止痛、退热和抗炎药物，几乎不溶于水。人们尝试通过各种助溶剂来提高1的水溶性。在乙醇中，其溶解度最高增加了8556倍，而在甘油中则仅增加了33倍（最低）。使用选定的助溶剂和水溶助长剂，配制了1的水针剂。
