Inhibitory and activatory receptors for HLA class I molecules in human natural killer cells. - Suppr | 超能文献

Inhibitory and activatory receptors for HLA class I molecules in human natural killer cells.

作者信息

Moretta A, Vitale M, Sivori S, Morelli L, Pende D, Bottino C

机构信息

Istituto Scientifico Tumori e Centro Biotecnologie Avanzate, Genova, Italia.

出版信息

Chem Immunol. 1996;64:77-87.

Abstract

摘要

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Inhibitory and activatory receptors for HLA class I molecules in human natural killer cells.

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CD94/NKG2 is the predominant inhibitory receptor involved in recognition of HLA-G by decidual and peripheral blood NK cells.CD94/NKG2是蜕膜和外周血自然杀伤细胞识别HLA-G所涉及的主要抑制性受体。

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Recognition of HLA-G by the NK cell receptor KIR2DL4 is not essential for human reproduction.自然杀伤细胞受体KIR2DL4对HLA - G的识别并非人类生殖所必需。

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Specific recognition of HLA-E, but not classical, HLA class I molecules by soluble CD94/NKG2A and NK cells.可溶性CD94/NKG2A和自然杀伤细胞对HLA-E具有特异性识别，而对经典的HLA I类分子则无此识别。

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HLA class-I-specific inhibitory receptor in human T lymphocytes: interference with T-cell functions.人类T淋巴细胞中HLA I类特异性抑制性受体：对T细胞功能的干扰

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