Morlese J F, Forrester T, Badaloo A, Del Rosario M, Frazer M, Jahoor F
US Department of Agriculture/Agricultural Research Service, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030-2600, USA.
Am J Clin Nutr. 1996 Dec;64(6):952-9. doi: 10.1093/ajcn/64.6.952.
The kinetic changes responsible for decreased plasma albumin and the relation between plasma albumin and the edema of protein-energy malnutrition (PEM) were investigated by measuring the plasma concentration, fractional (FSR) and intravascular absolute (ASR) synthesis rates of albumin in seven edematous and seven nonedematous children with PEM by using constant intragastric infusions of [2H3]leucine. Studies were done 2 d postadmission (study 1), 8 d postadmission (study 2), and at recovery (study 3). In study 1 there were no significant differences in plasma albumin concentrations in nonedematous and edematous children. In both groups, albumin concentrations but not FSRs were lower in studies 1 and 2 than in study 3. The ASR was lower only in edematous patients. These results suggest that repletion of the albumin pool of children with PEM is not mediated by changes in the FSR, and the edema of malnutrition is not solely due to hypoalbuminemia.
通过对7名水肿型和7名非水肿型蛋白质 - 能量营养不良（PEM）患儿持续胃内输注[2H3]亮氨酸，测量血浆白蛋白浓度、白蛋白分数合成率（FSR）和血管内绝对合成率（ASR），研究了导致血浆白蛋白降低的动力学变化以及血浆白蛋白与蛋白质 - 能量营养不良性水肿（PEM）之间的关系。在入院后2天（研究1）、入院后8天（研究2）和恢复时（研究3）进行研究。在研究1中，非水肿型和水肿型患儿的血浆白蛋白浓度无显著差异。在两组中，研究1和研究2的白蛋白浓度低于研究3，但FSR无差异。仅水肿型患者的ASR较低。这些结果表明，PEM患儿白蛋白池的补充不是由FSR的变化介导的，营养不良性水肿并非完全由低白蛋白血症引起。
