Lazetic S, Chang C, Houchins J P, Lanier L L, Phillips J H
Department of Human Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA.
J Immunol. 1996 Dec 1;157(11):4741-5.
CD94 receptors expressed on NK cells have been implicated in the recognition of certain HLA class I allotypes. We now demonstrate that CD94 glycoproteins form disulfide-bonded heterodimers with the NKG2A/B, NKG2C, and NKG2E glycoproteins. NKG2A/B possesses two immunoreceptor tyrosine-based inhibition motif (ITIM) sequences in its cytoplasmic domain, which may be responsible for the inhibitory function of these receptors, whereas other NKG2 proteins lack ITIMs and may potentially transmit positive signals. Structural heterogeneity in the NKG2 gene family and the formation of heterodimers with CD94 provides for the creation of a diverse NK cell repertoire.
自然杀伤细胞（NK细胞）上表达的CD94受体与某些HLA I类同种异型的识别有关。我们现在证明，CD94糖蛋白与NKG2A/B、NKG2C和NKG2E糖蛋白形成二硫键连接的异二聚体。NKG2A/B在其胞质结构域中具有两个基于免疫受体酪氨酸的抑制基序（ITIM）序列，这可能是这些受体抑制功能的原因，而其他NKG2蛋白缺乏ITIM，可能潜在地传递阳性信号。NKG2基因家族的结构异质性以及与CD94形成异二聚体，为创建多样化的NK细胞库提供了条件。
