Fast L D
Department of Medicine, Rhode Island Hospital and Brown University School of Medicine, Providence 02903, USA.
J Immunol. 1996 Dec 1;157(11):4805-10.
Blood transfusion can result in a variety of immunologic responses, including alloimmunization, transfusion-associated graft-versus-host disease, and immunosuppression that results in increased postoperative infection rate, and can also result in increased survival of allografts. One of the many factors influencing the resulting immunologic responses from a blood transfusion is the persistence of the donor leukocytes. A recent study has shown that almost all (99.9%) allogeneic leukocytes are removed within 2 days following transfusion but did not characterize the mechanism responsible for the rapid removal of allogeneic donor cells. Using a murine model these studies show that it is recipient CD8+ T cells that are responsible for the rapid elimination of allogeneic lymphocytes in naive recipients. Effective elimination was dependent on the donor/recipient combination and required that the donor cells express at least one MHC class I disparity to be recognized by the recipient CD8+ cells and that the donor cells also be able to induce additional responses that were needed by the CD8+ cells to manifest full activity. The perforin pathway was the predominant pathway used by the recipient CD8+ cells to mediate this elimination.
输血可导致多种免疫反应，包括同种免疫、输血相关移植物抗宿主病以及导致术后感染率增加的免疫抑制，还可导致同种异体移植物存活时间延长。影响输血所产生免疫反应的众多因素之一是供体白细胞的持续存在。最近一项研究表明，几乎所有（99.9%）异体白细胞在输血后2天内被清除，但未描述负责快速清除异体供体细胞的机制。利用小鼠模型，这些研究表明，在未致敏受体中，是受体CD8 + T细胞负责快速清除异体淋巴细胞。有效的清除取决于供体/受体组合，并且要求供体细胞表达至少一种与受体CD8 + 细胞相识别的MHC I类差异，还要求供体细胞能够诱导CD8 + 细胞表现出全部活性所需的其他反应。穿孔素途径是受体CD8 + 细胞介导这种清除所使用的主要途径。
