Palij M, Rosenblum A, Magura S, Handelsman L, Stimmel B
National Development and Research Institutes, Inc., New York, NY, USA.
J Addict Dis. 1996;15(4):13-37. doi: 10.1300/J069v15n04_02.
This study identifies factors that predict daily cocaine use among clients in a methadone maintenance program who participated in a cocaine treatment trial. Cocaine use decreased the longer clients remained in treatment, and the amount of cocaine used depended upon the day of the week, with Saturday typically having the greatest use and Sunday having the least. Logistic regression analyses showed that several other factors were related to daily cocaine use: peak cocaine craving, resistance to use cocaine, and several triggers or stimuli to use cocaine. These stimuli included receiving money, being offered cocaine, and seeing cocaine and/or related paraphernalia. However, even with these variables controlled, day of the week and time in treatment continued to be significant predictors. This suggests that (a) other time-varying variables need to be included in order to fully account for cocaine use variation from day to day and (b) time in treatment is a robust predictor of reduced cocaine use despite the strong influences of craving, external stimuli, and day of the week.
本研究确定了参与可卡因治疗试验的美沙酮维持治疗项目患者中预测每日使用可卡因情况的因素。治疗时间越长，可卡因使用量越少，且可卡因使用量取决于一周中的日期，通常周六使用量最大，周日最少。逻辑回归分析表明，其他几个因素与每日使用可卡因有关：可卡因渴望峰值、抵制使用可卡因以及几种使用可卡因的触发因素或刺激因素。这些刺激因素包括收到钱、有人提供可卡因以及看到可卡因和/或相关用具。然而，即使控制了这些变量，一周中的日期和治疗时长仍是显著的预测因素。这表明：（a）需要纳入其他随时间变化的变量，以便充分解释每日可卡因使用情况的变化；（b）尽管渴望、外部刺激和一周中的日期有很大影响，但治疗时长仍是可卡因使用量减少的有力预测因素。
