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[揭示莱姆病的脑膜乳头炎]

[Meningopapillitis disclosing Lyme disease].

作者信息

Gérard P, Canaple S, Rosa A

机构信息

Service de Neurologie, CHU Amiens.

出版信息

Rev Neurol (Paris). 1996 Jun-Jul;152(6-7):476-8.

PMID:8944247
Abstract

A 65 old year woman was admitted to the hospital for a low back pain, a fever and an elevated sedimentation rate. Four months later she noted a progressive visual loss first affected the right eye (visual acuity: 6/10) and then the left (visual acuity : 6/10). Fundus examination showed a bilateral papilledema. CT Scan and MRI were normal. A lumbar puncture disclosed a lymphocytic pleocytosis (68 leukocytes/mm3), an increase in protein level (1,9 g/l) and oligoclonal bands. A serologic test for B. Burgdorferi was positive both in blood (1/64 degrees) and in cerebrospinal fluid (> or = 1/128). The patient was treated with intravenous ceftriaxone 2 g daily for 2 weeks. Fifteen days later the low back pain had disappeared and the CSF cellular count had decreased to 20 leukocytes/mm3. Seven months later, CSF was normal (2 leukocytes/mm3, protein level: 0.65 g/l.); Titer against B. Burgdorferi had improved to 1/160 in serum and 1/16 in CSF; visual acuity had improved to 8/10 on left, and was the same on right.

摘要

一位65岁女性因腰痛、发热和血沉升高入院。四个月后,她发现视力逐渐下降,首先影响右眼(视力:6/10),然后是左眼(视力:6/10)。眼底检查显示双侧视乳头水肿。CT扫描和MRI均正常。腰椎穿刺显示淋巴细胞增多(68个白细胞/mm³)、蛋白水平升高(1.9 g/l)和寡克隆带。伯氏疏螺旋体血清学检测在血液中(1/64滴度)和脑脊液中(≥1/128)均为阳性。患者接受每日2 g静脉注射头孢曲松治疗2周。15天后,腰痛消失,脑脊液细胞计数降至20个白细胞/mm³。七个月后,脑脊液恢复正常(2个白细胞/mm³,蛋白水平:0.65 g/l);血清中抗伯氏疏螺旋体滴度提高到1/160,脑脊液中提高到1/16;左眼视力提高到8/10,右眼视力相同。

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