Nadal R, Prat G, Pallarés M, Hernández-Torres M, Ferré N
Departament de Psicobiologia i Metodologia en Ciències de la Salut, Facultat de Psicologia, Universitat Autònoma de Barcelona, Spain.
Psychopharmacology (Berl). 1996 Nov;128(1):45-53. doi: 10.1007/s002130050108.
The effect of bromocriptine (BRO), a D2 receptor agonist, on chronic oral ethanol (ETOH) self-administration was tested in a home-cage environment. Male Wistar rats (n = 77) were food deprived for 24 h. Then, a period of 15 days of limited-access (1 h/day) to food and to a sweetened ETOH solution was started [3% w/v of glucose and several concentrations of ETOH depending upon the group: 0% (control group). 1.5%, 5% or 10% v/v]. Later, another period started in which rats were maintained in a free-choice, two-bottle situation with food, tap-water and the sweetened solution available for 24 h/day, for 14 days. Following this period, BRO (5 mg/kg, SC) was administered, once daily, for 5 days, in the same continuous free-access conditions. ETOH consumption was also studied for 4 days after the last BRO injection. BRO increased ETOH self-administration throughout the 5-day period, regardless of the ETOH concentration available, in the rats with previous higher ETOH intake, without effect in the control animals. In the control rats, water intake was increased, whereas in the group that had access to the lowest ETOH concentration a decrease in water consumption was found. The enhanced ETOH drinking was maintained after BRO treatment for the animals with previous higher ETOH intake. BRO effects on water consumption were also maintained. These data suggest that BRO can potentiate ETOH intake and provide further support for the role of dopamine (DA) systems in mediating volitional oral intake of ETOH.
在笼内环境中测试了D2受体激动剂溴隐亭（BRO）对慢性口服乙醇（ETOH）自我给药的影响。雄性Wistar大鼠（n = 77）禁食24小时。然后，开始为期15天的限时（每天1小时）获取食物和甜乙醇溶液的阶段[3%（w/v）葡萄糖和几种不同浓度的乙醇，具体取决于组别：0%（对照组）、1.5%、5%或10%（v/v）]。之后，进入另一个阶段，在此阶段大鼠处于自由选择的两瓶情境中，食物、自来水和甜溶液每天24小时均可获取，持续14天。在此阶段之后，在相同的持续自由获取条件下，每天皮下注射一次BRO（5 mg/kg），持续5天。在最后一次注射BRO后还对乙醇消耗进行了4天的研究。在先前乙醇摄入量较高的大鼠中，无论可用的乙醇浓度如何，BRO在整个5天期间均增加了乙醇的自我给药量，而对对照动物没有影响。在对照大鼠中，水摄入量增加，而在可获取最低乙醇浓度的组中，水消耗量减少。对于先前乙醇摄入量较高的动物，BRO治疗后乙醇饮用量的增加得以维持。BRO对水消耗的影响也得以维持。这些数据表明，BRO可增强乙醇摄入量，并为多巴胺（DA）系统在介导自愿口服乙醇摄入中的作用提供了进一步的支持。
