Gustafson K J, Sweeney J D, Gibney J, Brandon T A
Bioengineering Program, Arizona State University, Tempe 85287-6006, USA.
ASAIO J. 1996 Sep-Oct;42(5):M360-4. doi: 10.1097/00002480-199609000-00011.
Skeletal muscle ventricle (SMV) conditioning typically results in reduced muscle performance. This study investigated the effects of progressive SMV resting pressure expansion and dynamic muscle training on SMV pumping capability. SMVs were formed from latissimus dorsi muscle in five goats. Three experimental SMVs were conditioned against a compliant pneumatic implant system. SMV resting pressure was progressively increased as the SMV adapted to each increment. Resting pressure rose from 40 to 100-120 mmHg over an 8 week period of time. Two control SMVs were conditioned against a non expanded incompressible implant. Both experimental and control SMVs were electrically burst stimulated for at least 6 weeks after an initial 2 week vascular delay interval. Results demonstrate that 1) experimental SMVs increased in volume; 2) SMV passive and active (evoked isovolumetric pressure) pressure-volume curves adapted to the increasing or static resting volume; and 3) two of three experimental SMVs generated greater stroke volumes than control SMVs across a range of counterpulsation pressures and electrical stimulation parameters. Progressive pressure expansion using a compliant implant system improved final SMV pumping performance and merits further investigation.
骨骼肌心室（SMV）调节通常会导致肌肉性能下降。本研究调查了渐进性SMV静息压力扩张和动态肌肉训练对SMV泵血能力的影响。从五只山羊的背阔肌形成SMV。三个实验性SMV通过一个顺应性气动植入系统进行调节。随着SMV适应每次增量，SMV静息压力逐渐增加。在8周的时间内，静息压力从40 mmHg升至100 - 120 mmHg。两个对照SMV通过一个未扩张的不可压缩植入物进行调节。在最初2周的血管延迟期后，实验性和对照性SMV均接受至少6周的电爆发刺激。结果表明：1）实验性SMV体积增加；2）SMV的被动和主动（诱发等容压力）压力 - 容积曲线适应于增加的或静态的静息容积；3）在一系列反搏压力和电刺激参数范围内，三个实验性SMV中的两个产生的每搏输出量大于对照SMV。使用顺应性植入系统进行渐进性压力扩张改善了最终的SMV泵血性能，值得进一步研究。
