含硫秋水仙碱衍生物的X射线分析
X-ray analysis of sulfur-containing colchicine derivatives.
作者信息
Koerntgen C, Margulis T N
出版信息
J Pharm Sci. 1977 Aug;66(8):1127-31. doi: 10.1002/jps.2600660819.
PMID:894499
Abstract
The crystal and molecular structures of deacetylthiocolchicine hydrochloride dihydrate and thiocolchicine hexahydrate were determined by X-ray diffraction. The replacement of oxygen by sulfur on the C ring methoxy group causes greater puckering of the troponoid ring. The conformation of one A ring methoxy group differs from that of colchicine derivatives that do not contain sulfur.
摘要
通过X射线衍射确定了盐酸去乙酰硫代秋水仙碱二水合物和硫代秋水仙碱六水合物的晶体结构和分子结构。C环甲氧基上的氧被硫取代导致环庚三烯酮环的褶皱更大。一个A环甲氧基的构象与不含硫的秋水仙碱衍生物的构象不同。
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