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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Bishop V S, Horwitz L D

J Physiol. 1977 Jul;269(2):355-70. doi: 10.1113/jphysiol.1977.sp011906.

A means of quantitating left ventricular performance in the conscious dog is presented. Changes in heart rate, stroke volume and cardiac output during elevation of left atrial pressure by acute volume expansion were measured in the conscious dog. 2. The changes in heart rate and stroke volume could be described by y = ym - (ym-yi)e-kp, where yi and ym are initial and maximum values of the variable and p is the change in mean left atrial pressure. 3. Because cardiac output is a derived variable (stroke volume X heart rate) its response is described by a multiple exponential relationship. 4. For a given initial heart rate and inotropic state, the stroke volume response is determined by the Frank-Starling mechanism and the pressure-volume characteristics of the myocardium.

本文介绍了一种在清醒犬中定量评估左心室功能的方法。通过急性容量扩张升高左心房压力时，测量清醒犬的心率、每搏量和心输出量的变化。2. 心率和每搏量的变化可用y = ym - (ym - yi)e - kp来描述，其中yi和ym分别为变量的初始值和最大值，p为平均左心房压力的变化。3. 由于心输出量是一个派生变量（每搏量×心率），其反应可用多重指数关系来描述。4. 对于给定的初始心率和心肌收缩力状态，每搏量的反应由Frank-Starling机制和心肌的压力-容量特性决定。

Bishop V S, Horwitz L D

J Physiol. 1977 Jul;269(2):355-70. doi: 10.1113/jphysiol.1977.sp011906.

A means of quantitating left ventricular performance in the conscious dog is presented. Changes in heart rate, stroke volume and cardiac output during elevation of left atrial pressure by acute volume expansion were measured in the conscious dog. 2. The changes in heart rate and stroke volume could be described by y = ym - (ym-yi)e-kp, where yi and ym are initial and maximum values of the variable and p is the change in mean left atrial pressure. 3. Because cardiac output is a derived variable (stroke volume X heart rate) its response is described by a multiple exponential relationship. 4. For a given initial heart rate and inotropic state, the stroke volume response is determined by the Frank-Starling mechanism and the pressure-volume characteristics of the myocardium.

本文介绍了一种在清醒犬中定量评估左心室功能的方法。通过急性容量扩张升高左心房压力时，测量清醒犬的心率、每搏量和心输出量的变化。2. 心率和每搏量的变化可用y = ym - (ym - yi)e - kp来描述，其中yi和ym分别为变量的初始值和最大值，p为平均左心房压力的变化。3. 由于心输出量是一个派生变量（每搏量×心率），其反应可用多重指数关系来描述。4. 对于给定的初始心率和心肌收缩力状态，每搏量的反应由Frank-Starling机制和心肌的压力-容量特性决定。