氨基青霉素从外翻大鼠肠段的吸收。
Absorption of amino penicillins from everted rat intestine.
作者信息
Dixon C, Mizen L W
出版信息
J Physiol. 1977 Aug;269(3):549-59. doi: 10.1113/jphysiol.1977.sp011914.
Abstract
- Using an in vitro everted gut sac method based on that of Wilson & Wiseman (1954), a number of amino penicillins were tested in order to identify the involvement of any specialized transport mechanisms in their absorption across rat intestine. 2. Only one of the amino penicillins, cyclacillin (1-amino-cyclohexyl penicillin) was shown to be actively transported. The other penicillins appeared to diffuse passively across the intestine. 3. Cyclacillin was found to concentrate against a gradient at 37 degrees C but not at 19 degrees C. 4. Transport of cyclacillin across the mucosal membrane was saturated at mucosal concentrations greater than 1000 microgram/ml. 5. The rate of the forward flux of cyclacillin was many times that of its back flux. 6. No relationship between the active transport of cyclacillin and that of amino acids could be demonstrated.
摘要
- 采用基于威尔逊和怀斯曼（1954年）方法的体外外翻肠囊法，对多种氨基青霉素进行了测试，以确定是否存在任何特殊转运机制参与其在大鼠肠道中的吸收。2. 氨基青霉素中只有一种，即环青霉素（1-氨基环己基青霉素）显示为主动转运。其他青霉素似乎是被动扩散穿过肠道。3. 发现环青霉素在37℃时能逆浓度梯度浓缩，但在19℃时则不能。4. 当黏膜浓度大于1000微克/毫升时环青霉素跨黏膜膜的转运达到饱和。5. 环青霉素正向通量的速率是其反向通量的许多倍。6. 未证明环青霉素的主动转运与氨基酸的主动转运之间存在关联。
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