Zhang B, Fattah A, Nakama H
Department of Public Health, Shinshu University School of Medicine, Nagano, Japan.
Hepatogastroenterology. 2000 Mar-Apr;47(32):414-8.
BACKGROUND/AIMS: A comparative study was carried out to clarify the clinicopathological features and survival rate of elderly patients with colorectal cancer diagnosed by immunochemical fecal occult blood screening.
The study subjects included 208 patients with colorectal cancer, who were divided into 2 groups based on their ages: 52 patients aged 75 years and over (older group) and 156 patients aged 50-74 years (younger group). The 2 groups were compared in terms of their individual factors, including site, size, Dukes' classification, histo-pathological type of their cancer lesions and 5-year survival rate.
There was a significant difference in prevalence of tumor sites between the older and younger groups (P < 0.05). Particularly, the frequency of right colon cancers was higher in the older group (34.6%) than in the younger group (20.5%), but there were no differences found in any other factors such as size, Dukes' classification, and histopathological type. Survival rate was almost the same between the 2 groups.
These results suggest that elderly patients are susceptible to right colon cancer but there is no difference in the clinicopathological characteristics and 5-year survival rate between older and younger patients with colorectal cancer detected by immunochemical fecal occult blood test. The older as well as younger people should be encouraged to attend the screening program for colorectal cancer by immunochemical fecal occult blood test.
背景/目的:开展一项比较研究,以阐明经免疫化学粪便潜血筛查诊断的老年结直肠癌患者的临床病理特征和生存率。
研究对象包括208例结直肠癌患者,根据年龄分为两组:52例年龄在75岁及以上(老年组)和156例年龄在50 - 74岁(年轻组)。比较两组患者的个体因素,包括肿瘤部位、大小、Dukes分期、癌灶组织病理类型及5年生存率。
老年组和年轻组肿瘤部位的患病率存在显著差异(P < 0.05)。特别是,老年组右半结肠癌的发生率(34.6%)高于年轻组(20.5%),但在大小、Dukes分期和组织病理类型等其他因素方面未发现差异。两组的生存率几乎相同。
这些结果表明,老年患者易患右半结肠癌,但经免疫化学粪便潜血检测发现的老年和年轻结直肠癌患者在临床病理特征和5年生存率方面没有差异。应鼓励老年人和年轻人参加免疫化学粪便潜血检测的结直肠癌筛查项目。