Means L W, Holsten R D, Long M, High K M
Department of Psychology, East Carolina University, Greenville, North Carolina 27858, USA. PSLLMEAN@ECUVM1
Neurobiol Learn Mem. 1996 Sep;66(2):167-75. doi: 10.1006/nlme.1996.0057.
Glucose has previously been shown to improve performance on memory tasks and to ameliorate performance deficits induced by scopolamine or morphine. To test the generality of these observations, Sprague-Dawley rats were trained to alternate choices to reach an escape platform in a two-choice circular water maze. The rats attained a high level of alternation, alternating on a mean of 9 of 10 daily trials. Daily glucose injections (100 and 250 mg/ kg) failed to facilitate acquisition of the alternation. Single injections of scopolamine (0.5, 1.0, and 2.0 mg/kg), but not methylscopolamine (0.5 mg/kg), and daily injections of scopolamine (0.5 mg/kg) or morphine (5.0 mg/kg) impaired alternation performance. The scopolamine- and morphine-induced deficits in alternation behavior were not ameliorated by pretrial glucose injections at doses which have previously been found to be effective (100 and 250 mg/kg). The mechanism of glucose facilitation of memory is currently unknown. The present results show that glucose given at previously established effective doses does not activate the mechanism or produces too weak an effect to be observed in water maze alternation.
先前的研究表明，葡萄糖能改善记忆任务的表现，并减轻由东莨菪碱或吗啡引起的行为缺陷。为了验证这些观察结果的普遍性，将斯普拉格-道利大鼠训练成在双选圆形水迷宫中交替选择以到达逃生平台。大鼠达到了较高的交替水平，平均在每天10次试验中有9次选择交替。每日注射葡萄糖（100和250毫克/千克）未能促进交替行为的习得。单次注射东莨菪碱（0.5、1.0和2.0毫克/千克）而非甲基东莨菪碱（0.5毫克/千克），以及每日注射东莨菪碱（0.5毫克/千克）或吗啡（5.0毫克/千克）会损害交替行为表现。在先前已发现有效的剂量（100和250毫克/千克）下，预先注射葡萄糖并不能改善由东莨菪碱和吗啡引起的交替行为缺陷。目前尚不清楚葡萄糖促进记忆的机制。目前的结果表明，以先前确定的有效剂量给予葡萄糖，并不会激活该机制，或者产生的效果过于微弱以至于在水迷宫交替实验中无法观察到。
