Nordahl T E, Kusubov N, Carter C, Salamat S, Cummings A M, O'Shora-Celaya L, Eberling J, Robertson L, Huesman R H, Jagust W, Budinger T F
Center for Functional Imaging, Lawrence Berkeley National Laboratory, University of California, Berkeley 94720, USA.
Neuropsychopharmacology. 1996 Dec;15(6):541-54. doi: 10.1016/S0893-133X(96)00098-X.
Regional cerebral glucose metabolic rates (rCMRglc) were compared in 18 unmedicated outpatients with schizophrenia and 11 normal controls using high resolution positron emission tomography (PET) and the tracer [F-18]-2-fluoro-2D-deoxyglucose (FDG). From previous work we expected to see abnormal hippocampal rCMRglc in the patients, but no striatal abnormalities. Trial-by-trial Stroop cognitive task, which has been shown to activate the anterior cingulate, was performed within a day of the PET study. As our patients performed abnormally on the Stroop we tested for a correlation between the anterior cingulate rCMRglc and Stroop performance. We found no whole slice cortical average glucose metabolic abnormalities. As, predicted we found abnormally decreased left hippocampal rCMRglc in the patients. No striatal or cingulate rCMRglc abnormalities were noted in patients, but they demonstrated a highly positive correlation between anterior and cingulate rCMRglc and Stroop facilitation. Patients with higher Stroop interference had more prominent hippocampal metabolic decreases. These localized temporal lobe abnormalities could account for some of the patient's positive symptoms and are consistent with recent findings in the literature.
使用高分辨率正电子发射断层扫描（PET）和示踪剂[F-18]-2-氟-2-脱氧葡萄糖（FDG），对18名未接受药物治疗的精神分裂症门诊患者和11名正常对照者的局部脑葡萄糖代谢率（rCMRglc）进行了比较。根据之前的研究，我们预计患者的海马体rCMRglc会出现异常，但纹状体不会出现异常。在PET研究的一天内，进行了逐次试验的Stroop认知任务，该任务已被证明可激活前扣带回。由于我们的患者在Stroop任务中表现异常，我们测试了前扣带回rCMRglc与Stroop表现之间的相关性。我们未发现整个脑片皮质平均葡萄糖代谢异常。正如预期的那样，我们发现患者左侧海马体rCMRglc异常降低。患者未发现纹状体或扣带回rCMRglc异常，但他们在前扣带回rCMRglc与Stroop易化之间表现出高度正相关。Stroop干扰较高的患者海马体代谢降低更为明显。这些局部颞叶异常可能解释了患者的一些阳性症状，并且与文献中的最新发现一致。
