Middleton E
J Membr Biol. 1977 Jun 3;34(1):93-101. doi: 10.1007/BF01870295.
A space-filling model of the inulin molecule, based solely on physico-chemical data in the literature, indicates that the gross shape of the solvated molecule is a cylinder having semi-length 25 A and radius 10 A. The axial dimensions of this model very nearly equal the equivalent estimates (25 and 10.5 A) previously determined by studying restricted passage of inulin through artificial membranes of known pore size (E. Middleton, J. Membrane Biol. 20:347, 1975). The good agreement between these independent in-vitro studies--neither of which depends on ultrafiltration theory--strongly suggests that glomerular pore size is considerably greater than predicted by the theory.
基于文献中的物理化学数据构建的菊粉分子填充模型表明，溶剂化分子的整体形状是一个半长为25埃、半径为10埃的圆柱体。该模型的轴向尺寸与之前通过研究菊粉在已知孔径的人工膜中的受限通过情况所确定的等效估计值（25埃和10.5埃）非常接近（E. 米德尔顿，《膜生物学杂志》20:347，1975年）。这些独立的体外研究结果高度一致——且两者均不依赖超滤理论——有力地表明肾小球孔径远大于该理论的预测值。
