Ventura M T, Casale G, Cenci L, Tursi A
Department of Allergology and Clinical Immunology, University of Bari, Italy.
Allergy. 1996 Nov;51(11):777-81.
This paper investigated the chemotactic capacity of blood eosinophils (EOS) in response to C5a and formyl-leucyl-phenylalanine (FMLP) in 15 Parietaria-pollen-allergic patients with mild asthma during the Parietaria pollen season. Data showed that EOS chemotaxis toward C5a was significantly reduced during the peak pollen count, compared with the values obtained in normal subjects. On the other hand, FMLP could induce EOS chemotactic activity only in Parietaria-allergic patients, the highest value being registered during the height of the Parietaria season. In vitro cimetidine modulation of chemotactic function in comparison with C5a led to a recovery of the impaired results obtained in the presence of high histamine levels. Moreover, diphenhydramine preincubation of EOS induced a reduction of the enhanced chemotactic activity obtained with low concentrations. The data suggest that different serum histamine levels give rise to an impaired immune-phlogistic response in allergic patients and that histamine-receptor antagonists may modulate this effect.
本文研究了15名患有轻度哮喘的墙草花粉过敏患者在墙草花粉季节期间，血液嗜酸性粒细胞（EOS）对C5a和甲酰亮氨酰苯丙氨酸（FMLP）的趋化能力。数据显示，与正常受试者相比，在花粉计数高峰期间，EOS对C5a的趋化作用显著降低。另一方面，FMLP仅能在墙草过敏患者中诱导EOS趋化活性，最高值出现在墙草季节高峰期。与C5a相比，西咪替丁对趋化功能的体外调节导致在高组胺水平下受损结果的恢复。此外，EOS预先用苯海拉明孵育会导致低浓度时增强的趋化活性降低。数据表明，不同的血清组胺水平会导致过敏患者免疫炎症反应受损，组胺受体拮抗剂可能会调节这种效应。
