体外受精后初始血清β-人绒毛膜促性腺激素水平对妊娠结局的预测价值。
The predictive value of an initial serum beta human chorionic gonadotropin level for pregnancy outcome following in vitro fertilization.
作者信息
Qasim S M, Callan C, Choe J K
机构信息
Cooper Center for Reproductive Endocrinology, Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology, Marlton, New Jersey, USA.
出版信息
J Assist Reprod Genet. 1996 Oct;13(9):705-8. doi: 10.1007/BF02066422.
PURPOSE
Our purpose was to assess the predictive value for pregnancy outcome of an initial serum quantitative beta-hCG measurement obtained 11 or 12 days after embryo transfer in an in vitro fertilization program.
METHODS
A prospective, descriptive study of 153 pregnancies achieved via in vitro fertilization-embryo transfer was performed. Initial beta-hCG levels and subsequent pregnancy outcomes were compared.
RESULTS
The overall mean initial beta-hCG level was 91 +/- 85.8 mIU/ml for normal (singleton, multiple-gestation) pregnancies and 29 +/- 24.9 mIU/ml for abnormal (miscarriage, ectopic) pregnancies (P < 0.01; power, > 80%). While 93.9% of patients with initial beta-hCG levels > or = 42 mIU/ml had normal pregnancies, 56.4% of those with initial levels < 42 mIU/ml experienced abnormal outcomes. With 42 mIU/ml as the cutoff level for predicting a normal pregnancy, this screening test yielded a sensitivity of 79.3% and a specificity of 83.8%.
CONCLUSIONS
Initial serum beta-hCG levels obtained 11 or 12 days after embryo transfer may be predictive of pregnancy outcome in an in vitro fertilization program.
目的
我们的目的是评估在体外受精程序中，胚胎移植后11天或12天进行的首次血清定量β - hCG测量对妊娠结局的预测价值。
方法
对153例通过体外受精 - 胚胎移植实现的妊娠进行了一项前瞻性描述性研究。比较了初始β - hCG水平和随后的妊娠结局。
结果
正常（单胎、多胎妊娠）妊娠的总体平均初始β - hCG水平为91±85.8 mIU/ml，异常（流产、异位妊娠）妊娠为29±24.9 mIU/ml（P < 0.01；检验效能> 80%）。初始β - hCG水平≥42 mIU/ml的患者中，93.9%为正常妊娠，而初始水平< 42 mIU/ml的患者中，56.4%出现异常结局。以42 mIU/ml作为预测正常妊娠的临界值，该筛查试验的敏感性为79.3%，特异性为83.8%。
结论
胚胎移植后11天或12天获得的初始血清β - hCG水平可能对体外受精程序中的妊娠结局具有预测作用。
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