β-人绒毛膜促性腺激素作为体外受精-胚胎移植患者妊娠结局的监测指标

Beta-human chorionic gonadotropin as a monitor of pregnancy outcome in in vitro fertilization-embryo transfer patients.

作者信息

Liu H C, Kreiner D, Muasher S J, Jones G, Jones H, Rosenwaks Z

机构信息

Eastern Virginia Medical School, Howard and Georgeanna Jones Institute for Reproductive Medicine, Norfolk 23507.

出版信息

Fertil Steril. 1988 Jul;50(1):89-94. doi: 10.1016/s0015-0282(16)60014-6.

DOI:10.1016/s0015-0282(16)60014-6

PMID:3384122

Abstract

Serum human chorionic gonadotropin (hCG) was studied to test its predictability of pregnancy outcome in in vitro fertilization (IVF) patients. The mean +/- standard deviation of serum hCG concentration related to the day complete clearance of exogenous hCG was derived from 47 single term pregnancies as a normal range. This range can be used to predict spontaneous abortion (77%), multiple pregnancy (60%), and abortion in multiple-sac pregnancies terminating in the birth of fewer infants than the initial number of sacs (80%). The results also showed that our stimulation protocol did not affect the clearance rate and doubling time of endogenous hCG or implantation time as suggested by the time of endogenous hCG detection and that spontaneous abortion may be due to late implantation.

摘要

研究血清人绒毛膜促性腺激素（hCG）以测试其在体外受精（IVF）患者中对妊娠结局的预测性。将47例单胎足月妊娠中外源性hCG完全清除日的血清hCG浓度均值±标准差作为正常范围。该范围可用于预测自然流产（77%）、多胎妊娠（60%）以及多孕囊妊娠中出生婴儿数少于初始孕囊数的流产情况（80%）。结果还表明，我们的刺激方案并未如内源性hCG检测时间所提示的那样影响内源性hCG的清除率、翻倍时间或着床时间，且自然流产可能归因于着床延迟。