Curran E J, Akil H, Watson S J
University of Michigan, Mental Health Research Institute, Ann Arbor 48109-0720, USA.
Neurochem Res. 1996 Nov;21(11):1425-35. doi: 10.1007/BF02532384.
Amphetamine-, cocaine-, and morphine-induced c-fos expression patterns were examined following an injection protocol that has previously been shown to produce behavioral sensitization and enhanced dopamine release in the striatal complex. Drug-specific c-fos patterns were observed in both acute and sensitization injection paradigms. A sensitization pretreatment schedule did, however, alter the c-fos expression patterns induced by all the drugs in the caudate putamen, nucleus accumbens, and the cerebral cortex. In some striatal and cortical regions, there was an increase or recruitment of cells expressing c-fos whereas in others there was an apparent decrease or inhibition. The somatosensory cortex was one area where pretreatment with all three drugs increased c-fos expression. The results suggest that the neuronal networks that are modulated by systemic drug injections in the sensitized animal differ from those affected by the initial drug exposure; areas of overlap may indicate common "sensitization' circuits.
按照先前已证明能在纹状体复合体中产生行为敏化和增强多巴胺释放的注射方案，检测了苯丙胺、可卡因和吗啡诱导的c-fos表达模式。在急性和敏化注射范式中均观察到了药物特异性的c-fos模式。然而，敏化预处理方案确实改变了尾状壳核、伏隔核和大脑皮质中所有药物诱导的c-fos表达模式。在一些纹状体和皮质区域，表达c-fos的细胞有所增加或出现新的表达，而在其他区域则明显减少或受到抑制。躯体感觉皮质是一个所有三种药物预处理均会增加c-fos表达的区域。结果表明，致敏动物中由全身药物注射调节的神经网络与受初始药物暴露影响的神经网络不同；重叠区域可能表明存在共同的“敏化”回路。
