Norman A B, Lu S Y, Klug J M, Norgren R B
Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267.
Brain Res. 1993 Feb 12;603(1):125-8. doi: 10.1016/0006-8993(93)91308-f.
D-Amphetamine transiently stimulates the expression of the immediate-early response gene, c-fos, in rat striatal cell nuclei. D-Amphetamine (2.5 mg/kg i.p.) induced a significantly greater expression of Fos-like immunoreactivity in striatum of rats treated three days previously with D-amphetamine compared to rats treated three days previously with saline. This increase in the expression of Fos-like immunoreactivity in rat striatum was characterized by a significantly greater number of immunoreactive nuclei and a significant increase in the intensity of the immunoreactivity. This sensitization of c-fos expression following a repeated administration of D-amphetamine indicates an increased activation of post-synaptic elements in rat striatum.
