Maish W A, Hampton E M, Whitsett T L, Shepard J D, Lovallo W R
School of Pharmacy, University of Missouri at Kansas City 64108, USA.
Pharmacotherapy. 1996 Nov-Dec;16(6):1046-52.
The influence of grapefruit juice (GFJ) on caffeine's metabolism and the hemodynamic effects of this potential food interaction were studied in 10 normotensive volunteers. In this crossover study, caffeine (3.3 mg/kg) and water or caffeine and GFJ were given to participants. Nine serum caffeine concentrations were determined within 24 hours of each phase. In another phase of this study, caffeine was given with multiple GFJ doses to 6 of the 10 participants. Ambulatory blood pressure (BP) monitors were used for 12 hours to assess treatment hemodynamic effects. The mean area under the serum caffeine concentration-time curve (AUC0-infinity) values +/- SD for the caffeine with water group, caffeine with GFJ group, and caffeine with multiple GFJ group were 47.0 +/- 10.8, 48.7 +/- 15.2, and 49.6 +/- 7.0 micrograms/ml.hr, respectively (NS). There was no significant difference on the ambulatory systolic BP, diastolic BP, percentage of the time with a diastolic BP greater than 90 mm Hg, or heart rate area under the effect curves. We conclude that grapefruit juice had no effect on caffeine pharmacokinetics or hemodynamic effects.
在10名血压正常的志愿者中研究了葡萄柚汁（GFJ）对咖啡因代谢的影响以及这种潜在食物相互作用的血流动力学效应。在这项交叉研究中，向参与者给予咖啡因（3.3毫克/千克）和水，或咖啡因和葡萄柚汁。在每个阶段的24小时内测定9次血清咖啡因浓度。在该研究的另一个阶段，向10名参与者中的6名给予多次剂量的葡萄柚汁和咖啡因。使用动态血压（BP）监测仪12小时以评估治疗的血流动力学效应。咖啡因与水组、咖啡因与葡萄柚汁组以及咖啡因与多次剂量葡萄柚汁组的血清咖啡因浓度-时间曲线下平均面积（AUC0-∞）值±标准差分别为47.0±10.8、48.7±15.2和49.6±7.0微克/毫升·小时（无显著性差异）。动态收缩压、舒张压、舒张压大于90毫米汞柱的时间百分比或效应曲线下的心率面积均无显著差异。我们得出结论，葡萄柚汁对咖啡因的药代动力学或血流动力学效应没有影响。
