Chan T Y
Department of Clinical Pharmacology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong.
Vet Hum Toxicol. 1996 Dec;38(6):443-4.
The prince of Wales Hospital is in a unique position for the study of the actual incidence of acetaminophen poisoning in Hong Kong because it is the sole general teaching hospital in the New Territories East and the age and sex distribution of the population in the region are readily available. Between 1991 and 1994, the rate of admission in subjects aged > or = 15 years slightly increased from 5.7 to 7.3/100,000. In both 1991 and 1994, the highest rates in women were in the 15-19 age group (from 22.8 to 53.0/100,000) and in men in the 25-29 age group (from 10.5 to 6.0/100,000). The rates of admission with toxic plasma acetaminophen concentrations were higher in 1994 than in 1991 (10.8 vs 0.6/100,000). The annual incidence of acetaminophen-induced liver damage remained unchanged (0.3/100,000). None of the patients with liver damage developed fulminant liver failure. There were no deaths. Thus, acetaminophen poisoning appears to cause less fulminant liver failure and deaths in Hong Kong than in other Western societies. Reasons for such differences need to be better understood.
威尔士亲王医院在研究香港对乙酰氨基酚中毒的实际发病率方面具有独特地位，因为它是新界东唯一的一家综合教学医院，该地区人口的年龄和性别分布情况很容易获取。1991年至1994年期间，15岁及以上人群的入院率从5.7/10万略有上升至7.3/10万。在1991年和1994年，女性入院率最高的年龄段均为15 - 19岁（从22.8/10万升至53.0/10万），男性入院率最高的年龄段为25 - 29岁（从10.5/10万降至6.0/10万）。1994年血浆对乙酰氨基酚浓度达到中毒水平的入院率高于1991年（10.8/10万对0.6/10万）。对乙酰氨基酚所致肝损伤的年发病率保持不变（0.3/10万）。肝损伤患者均未发生暴发性肝衰竭，也无死亡病例。因此，在香港，对乙酰氨基酚中毒导致的暴发性肝衰竭和死亡似乎比其他西方社会少。这种差异的原因有待进一步深入了解。
