[Safety evaluation of KW-1062. III. Investigation of maximum safety dose on subacute toxicity studies in dogs (author's transl)].

In previous subacute toxicity studies by intramuscular administration carried out in Beagle dogs for 30 days, its maximum safety dose was not confirmed because renal tubular disorder was observed slightly at the dose of 25 mg/kg. Therefore subacute intramuscular toxicity studies were carried out again to investigate maximum safety dose using lower doses (4, 10 mg/kg). As the result of studies, the maximum safety dose was considered to be 10 mg/kg because there were no abnormal changes at both doses.