Nakagawa H, Imokawa G
Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan.
Pigment Cell Res. 1996 Aug;9(4):175-8. doi: 10.1111/j.1600-0749.1996.tb00106.x.
Chemical and ultrastructural studies were conducted to define the relationship between type of melanogenesis and fine structures of melanosomes in normal human epidermal melanocytes. Chemical analysis of epidermal melanin demonstrated that the ratio of eumelanin/pheomelanin varied individually, ranging from 1.31 to exclusively eumelanic. Ultrastructural analysis of fine structures of melanosomes revealed that spheroid melanosomes were frequently observed in melanocytes of the epidermis whose eumelanin/ pheomelanin ratio was less than 5. Conversely, ellipsoid melanosomes predominated in melanocytes of the epidermis whose ratio was more than 10. On the basis of these findings, it seems reasonable to conclude that 1) normal human epidermal melanocytes synthesize both eumelanin and pheomelanin and 2) pheomelanin synthesis may be characterized by the presence of spheroid melanosomes whereas eumelanin synthesis is ascribed to ellipsoid melanosomes.
开展了化学和超微结构研究，以确定正常人表皮黑素细胞中黑素生成类型与黑素小体精细结构之间的关系。对表皮黑色素的化学分析表明，真黑素/褐黑素的比例因人而异，范围从1.31到完全为真黑素。对黑素小体精细结构的超微结构分析显示，在真黑素/褐黑素比例小于5的表皮黑素细胞中经常观察到球形黑素小体。相反，在比例大于10的表皮黑素细胞中，椭圆形黑素小体占主导地位。基于这些发现，似乎有理由得出以下结论：1）正常人表皮黑素细胞合成真黑素和褐黑素；2）褐黑素的合成可能以球形黑素小体的存在为特征，而真黑素的合成则归因于椭圆形黑素小体。
