Maeda K, Naganuma M, Fukuda M, Matsunaga J, Tomita Y
Shiseido Research Center, Yokohama, Japan.
Pigment Cell Res. 1996 Aug;9(4):204-12. doi: 10.1111/j.1600-0749.1996.tb00110.x.
Normal human melanocytes in culture became enlarged and dendritic after a 2-day incubation with either the pituitary (beta-MSH, a potent analog of alpha-MSH, ACTH, FSH and LH) or the ovarian (estradiol, estriol and progesterone) hormones. Under the same experimental conditions, pituitary hormones also increased both the tyrosinase activity and tyrosinase-related protein-1 (TRP-1) while ovarian hormones increased TRP-1 but not tyrosinase activity. The results suggest that pituitary and ovarian hormones possibly induce hyperpigmentation of the skin by stimulating the melanogenesis in epidermal melanocytes, and that estradiol and progesterone may be involved in the pathogenesis of melasma (chloasma) usually developing between early adulthood and menopause in which a high concentration of serum ovarian hormones was maintained.
在培养环境中，正常人类黑素细胞在与垂体激素（β-促黑素，α-促黑素、促肾上腺皮质激素、促卵泡激素和促黄体生成素的一种有效类似物）或卵巢激素（雌二醇、雌三醇和孕酮）孵育2天后会变大并出现树突状。在相同实验条件下，垂体激素还会增加酪氨酸酶活性和酪氨酸酶相关蛋白-1（TRP-1），而卵巢激素会增加TRP-1，但不会增加酪氨酸酶活性。结果表明，垂体和卵巢激素可能通过刺激表皮黑素细胞中的黑素生成来诱导皮肤色素沉着过度，并且雌二醇和孕酮可能参与了通常在成年早期至绝经期间发生的黄褐斑（肝斑）的发病机制，在此期间血清卵巢激素维持在高浓度水平。
