乌司他丁改善大鼠急性缺血性肾损伤。
Ulinastatin ameliorates acute ischemic renal injury in rats.
作者信息
Nakahama H, Obata K, Sugita M
机构信息
Fifth Department of Internal Medicine, Hyogo College of Medicine, Japan.
出版信息
Ren Fail. 1996 Nov;18(6):893-8. doi: 10.3109/08860229609047715.
Effects of ulinastatin (a Kunitz-type proteinase inhibitor) administration was examined in a model of acute ischemic renal injury induced by bilateral renal artery occlusion in rats. Compared with rats administered vehicle, rats administered ulinastatin (150,000 U/kg body weight) intravenously 30 min preischemia had significantly lower serum creatinine and blood urea nitrogen, and much less injury evident by examination of kidney histologies over the course of 48 h postreperfusion. We conclude that ulinastatin exerts a protective effect against ischemic renal injury.
在大鼠双侧肾动脉闭塞诱导的急性缺血性肾损伤模型中，研究了乌司他丁（一种库尼兹型蛋白酶抑制剂）给药的效果。与给予赋形剂的大鼠相比，在缺血前30分钟静脉注射乌司他丁（150,000 U/kg体重）的大鼠，血清肌酐和血尿素氮显著降低，并且在再灌注后48小时的肾脏组织学检查中明显可见损伤程度轻得多。我们得出结论，乌司他丁对缺血性肾损伤具有保护作用。
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