Otley C C, Roenigk R K
Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA.
Semin Cutan Med Surg. 1996 Sep;15(3):145-54. doi: 10.1016/s1085-5629(96)80005-8.
Trichloroacetic acid (TCA) alone or in combination with other agents is the mainstay of medium-depth chemical peels. Indications for medium-depth chemical peels include both medical conditions, such as diffuse photodamage with contiguous actinic keratoses, and cosmetic conditions, such as the aging face and solar lentiginosis. Medium-depth chemical peeling with TCA is relatively simple and is associated with a favorable risk/benefit ratio. However, proper patient selection, with attention to both medical and psychological factors, requires significant experience. The histological basis of the rejuvenating effects of TCA peels is well established, with a consistent correlation between wound depth and TCA concentration. The clinical effects of medium-depth chemical peels are generally gratifying for both patient and physician.
单独使用三氯乙酸（TCA）或与其他药物联合使用是中度化学剥脱术的主要手段。中度化学剥脱术的适应证包括医学状况，如伴有连续性光化性角化病的弥漫性光损伤，以及美容状况，如面部老化和日光性雀斑样痣。使用TCA进行中度化学剥脱相对简单，且风险/收益比良好。然而，要正确选择患者，同时关注医学和心理因素，需要丰富的经验。TCA剥脱术的年轻化效果的组织学基础已得到充分证实，伤口深度与TCA浓度之间存在一致的相关性。中度化学剥脱术的临床效果通常令患者和医生都满意。
