• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Interstrand cross-linking reaction in triplexes containing a monofunctional transplatin-adduct.含单功能反式铂加合物的三链体中的链间交联反应。
Nucleic Acids Res. 1996 Nov 15;24(22):4519-24. doi: 10.1093/nar/24.22.4519.
2
Chemical versatility of transplatin monofunctional adducts within multiple site-specifically platinated DNA.多位点特异性铂化 DNA 中反式铂单功能加合物的化学多样性
Biochemistry. 1997 Jun 17;36(24):7281-7. doi: 10.1021/bi9703148.
3
Intrastrand cross-links are not formed in the reaction between transplatin and native DNA: relation with the clinical inefficiency of transplatin.顺铂与天然DNA反应中不会形成链内交联：与顺铂临床低效性的关系。
Nucleic Acids Res. 1995 Jul 11;23(13):2381-8. doi: 10.1093/nar/23.13.2381.
4
Instability of the monofunctional adducts in cis-[Pt(NH3)2(N7-N-methyl-2-diazapyrenium)Cl](2+)-modified DNA: rates of cross-linking reactions in cis-platinum-modified DNA.顺式-[Pt(NH₃)₂(N₇-N-甲基-2-二氮杂芘鎓)Cl](2+)修饰的DNA中单一功能加合物的不稳定性：顺铂修饰的DNA中的交联反应速率
Nucleic Acids Res. 1993 Dec 25;21(25):5846-51. doi: 10.1093/nar/21.25.5846.
5
Transplatin-modified oligonucleotides as modulators of gene expression.顺铂修饰的寡核苷酸作为基因表达的调节剂。
Pharmacol Ther. 2000 Mar;85(3):175-81. doi: 10.1016/s0163-7258(99)00058-3.
6
Fast interstrand cross-linking of cisplatin-DNA monoadducts compared with intrastrand chelation: a kinetic study using hairpin-stabilized duplex oligonucleotides.与链内螯合相比，顺铂-DNA单加合物的快速链间交联：使用发夹稳定双链寡核苷酸的动力学研究。
Chemistry. 2002 Mar 1;8(5):1144-50. doi: 10.1002/1521-3765(20020301)8:5<1144::aid-chem1144>3.0.co;2-k.
7
Transplatin-modified oligo(2'-O-methyl ribonucleotide)s: a new tool for selective modulation of gene expression.顺铂修饰的寡聚（2'-O-甲基核糖核苷酸）：一种选择性调控基因表达的新工具。
Biochemistry. 1997 Mar 11;36(10):2925-31. doi: 10.1021/bi962695f.
8
Long range 1,4 and 1,6-interstrand cross-links formed by a trinuclear platinum complex. Minor groove preassociation affects kinetics and mechanism of cross-link formation as well as adduct structure.由三核铂配合物形成的长程1,4和1,6链间交联。小沟预结合影响交联形成的动力学和机制以及加合物结构。
J Am Chem Soc. 2004 Feb 25;126(7):2166-80. doi: 10.1021/ja036105u.
9
NMR solution structure of a DNA dodecamer containing a transplatin interstrand GN7-CN3 cross-link.含有反式铂链间 GN7-CN3 交联的 DNA 十二聚体的核磁共振溶液结构
Nucleic Acids Res. 1999 Nov 1;27(21):4261-8. doi: 10.1093/nar/27.21.4261.
10
Replacement of an NH(3) by an iminoether in transplatin makes an antitumor drug from an inactive compound.在反式铂中用亚胺醚取代氨会使一种无活性的化合物变成一种抗肿瘤药物。
Mol Pharmacol. 2000 Dec;58(6):1525-35. doi: 10.1124/mol.58.6.1525.

引用本文的文献

1
2-Trifluoromethyl-6-mercurianiline Nucleotide, a Sensitive F NMR Probe for Hg(II)-mediated Base Pairing.2-三氟甲基-6-汞代鸟嘌呤核苷酸，一种用于检测 Hg(II)-介导碱基配对的灵敏 F NMR 探针。
J Org Chem. 2022 Jan 7;87(1):137-146. doi: 10.1021/acs.joc.1c02056. Epub 2021 Dec 14.
2
A Click Chemistry Approach to Targeted DNA Crosslinking with cis-Platinum(II)-Modified Triplex-Forming Oligonucleotides.点击化学法用于靶向 DNA 交联的顺铂（II）修饰的三链体形成寡核苷酸。
Angew Chem Int Ed Engl. 2022 Jan 17;61(3):e202110455. doi: 10.1002/anie.202110455. Epub 2021 Dec 3.
3
Different Effects of Cisplatin and Transplatin on the Higher-Order Structure of DNA and Gene Expression.顺铂和反式铂对 DNA 高级结构和基因表达的不同影响。
Int J Mol Sci. 2019 Dec 19;21(1):34. doi: 10.3390/ijms21010034.
4
Oligonucleotide⁻Palladacycle Conjugates as Splice-Correcting Agents.寡核苷酸⁻钯环合物作为剪接校正剂。
Molecules. 2019 Mar 26;24(6):1180. doi: 10.3390/molecules24061180.
5
Palladacyclic Conjugate Group Promotes Hybridization of Short Oligonucleotides.钯环共轭基团促进短寡核苷酸杂交。
Int J Mol Sci. 2018 May 28;19(6):1588. doi: 10.3390/ijms19061588.
6
Inhibition of transcription by platinated triplex-forming oligonucleotides.铂结合三链形成寡核苷酸对转录的抑制作用。
J Biol Inorg Chem. 2012 Dec;17(8):1197-208. doi: 10.1007/s00775-012-0933-9. Epub 2012 Sep 11.
7
Probing platinum-adenine-n3 adduct formation with DNA minor-groove binding agents.探测铂-腺嘌呤-n3 加合物与 DNA 小沟结合剂的形成。
Chem Res Toxicol. 2010 Jul 19;23(7):1148-50. doi: 10.1021/tx100170p.
8
Transplatin-conjugated triplex-forming oligonucleotides form adducts with both strands of DNA.顺铂偶联的三链形成寡核苷酸与 DNA 的两条链形成加合物。
Bioconjug Chem. 2009 Dec;20(12):2222-30. doi: 10.1021/bc900008s.
9
Cross-linking to an interrupted polypurine sequence with a platinum-modified triplex-forming oligonucleotide.通过铂修饰的三链形成寡核苷酸与中断的聚嘌呤序列交联。
J Biol Inorg Chem. 2009 Aug;14(6):873-81. doi: 10.1007/s00775-009-0499-3. Epub 2009 Apr 7.
10
Factors influencing the extent and selectivity of alkylation within triplexes by reactive G/A motif oligonucleotides.影响反应性G/A基序寡核苷酸在三链体中烷基化程度和选择性的因素。
Nucleic Acids Res. 1997 Oct 15;25(20):4123-31. doi: 10.1093/nar/25.20.4123.

本文引用的文献

1
Oligonucleotide directed triple helix formation.寡核苷酸定向三链螺旋形成。
Curr Opin Struct Biol. 1996 Jun;6(3):327-33. doi: 10.1016/s0959-440x(96)80051-0.
2
Stable triple helices formed by oligonucleotide N3'-->P5' phosphoramidates inhibit transcription elongation.由寡核苷酸N3'→P5'氨基磷酸酯形成的稳定三螺旋结构抑制转录延伸。
Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4365-9. doi: 10.1073/pnas.93.9.4365.
3
DNA double helix promotes a linkage isomerization reaction in trans-diamminedichloroplatinum(II)-modified DNA.DNA双螺旋促进反式二氯二氨铂（II）修饰的DNA中的连接异构化反应。
Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):8147-51. doi: 10.1073/pnas.91.17.8147.
4
H-DNA and related structures.H-DNA及相关结构。
Annu Rev Biophys Biomol Struct. 1994;23:541-76. doi: 10.1146/annurev.bb.23.060194.002545.
5
Linkage isomerization reaction of intrastrand cross-links in trans-diamminedichloroplatinum(II)-modified single-stranded oligonucleotides.反式二氯二氨合铂（II）修饰的单链寡核苷酸中链内交联的键合异构化反应
Nucleic Acids Res. 1995 Mar 25;23(6):949-53. doi: 10.1093/nar/23.6.949.
6
Nucleic acid hybridization: triplex stability and energetics.核酸杂交：三链体稳定性与能量学
Annu Rev Biophys Biomol Struct. 1995;24:319-50. doi: 10.1146/annurev.bb.24.060195.001535.
7
DNA analogues with nonphosphodiester backbones.具有非磷酸二酯主链的DNA类似物。
Annu Rev Biophys Biomol Struct. 1995;24:167-83. doi: 10.1146/annurev.bb.24.060195.001123.
8
Intrastrand cross-links are not formed in the reaction between transplatin and native DNA: relation with the clinical inefficiency of transplatin.顺铂与天然DNA反应中不会形成链内交联：与顺铂临床低效性的关系。
Nucleic Acids Res. 1995 Jul 11;23(13):2381-8. doi: 10.1093/nar/23.13.2381.
9
Origins of the large differences in stability of DNA and RNA helices: C-5 methyl and 2'-hydroxyl effects.DNA和RNA螺旋稳定性巨大差异的起源：C-5甲基和2'-羟基效应。
Biochemistry. 1995 Mar 28;34(12):4125-32. doi: 10.1021/bi00012a031.
10
[Epidemiological analysis of the influenza virus A carrier state in healthy children].[健康儿童甲型流感病毒携带状态的流行病学分析]
Vopr Virusol. 1983 May-Jun(3):286-9.

含单功能反式铂加合物的三链体中的链间交联反应。

Interstrand cross-linking reaction in triplexes containing a monofunctional transplatin-adduct.

作者信息

Colombier C, Lippert B, Leng M

机构信息

Centre de Biophysique Moléculaire, CNRS, Orléans, France.

出版信息

Nucleic Acids Res. 1996 Nov 15;24(22):4519-24. doi: 10.1093/nar/24.22.4519.

DOI:10.1093/nar/24.22.4519
PMID:8948644
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC146263/
Abstract

Our aim was to determine whether a single transplatin monofunctional adduct, either trans-[Pt(NH3)2(dC)Cl]+ or trans-[Pt(NH3)2(dG)Cl]+ within a homopyrimidine oligonucleotide, could further react and form an interstrand cross-link once the platinated oligonucleotide was bound to the complementary duplex. The single monofunctional adduct was located at either the 5' end or in the middle of the platinated oligonucleotide. In all the triplexes, specific interstrand cross-links were formed between the platinated Hoogsteen strand and the complementary purine-rich strand. No interstrand cross-links were detected between the platinated oligonucleotides and non-complementary DNA. The yield and the rate of the cross-linking reaction depend upon the nature and location of the monofunctional adducts. Half-lives of the monofunctional adducts within the triplexes were in the range 2-6 h. The potential use of the platinated oligonucleotides to modulate gene expression is discussed.

摘要

我们的目的是确定同型嘧啶寡核苷酸内的单个反式铂单功能加合物，即反式-[Pt(NH₃)₂(dC)Cl]⁺或反式-[Pt(NH₃)₂(dG)Cl]⁺，一旦铂化寡核苷酸与互补双链体结合，是否会进一步反应并形成链间交联。单个单功能加合物位于铂化寡核苷酸的5'端或中间位置。在所有三链体中，铂化的Hoogsteen链与富含嘌呤的互补链之间形成了特异性链间交联。在铂化寡核苷酸与非互补DNA之间未检测到链间交联。交联反应的产率和速率取决于单功能加合物的性质和位置。三链体内单功能加合物的半衰期在2至6小时范围内。文中讨论了铂化寡核苷酸在调节基因表达方面的潜在用途。