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[心肌梗死后的二级预防;β受体阻滞剂的作用]

[Secondary prevention after myocardial infarction; role of beta blockaders].

作者信息

Cohen-Solal A, Seknadji P, Czitrom D, Boudvillain O

机构信息

Service de cardiologie, hôpital Beaujon, Clichy.

出版信息

Arch Mal Coeur Vaiss. 1996 Aug;89 Spec No 3:43-6.

PMID:8949318
Abstract

The betablockers are the most important drugs in the secondary prevention after myocardial infarction. Several studies have shown that, in patients without a contraindication to these drugs, betablockers reduce the mortality and recurrence of infarction by about 25%. The best results observed in the subgroup of patients with criteria of severity (previous myocardial infarction or cardiac failure, left ventricular dysfunction, arrhythmias, residual ischaemia, occluded artery or triple vessel disease) has been shown in the APSI and BHAT studies where the reduction in mortality was almost 50% in the subgroup of patients with cardiac failure. The duration of treatment and the role of betablockers with respect to ACE inhibitors are not as clearcut in 1996.

摘要

β受体阻滞剂是心肌梗死后二级预防中最重要的药物。多项研究表明,在没有使用这些药物禁忌证的患者中,β受体阻滞剂可使死亡率和梗死复发率降低约25%。在APSI和BHAT研究中显示,在具有严重程度标准(既往心肌梗死或心力衰竭、左心室功能障碍、心律失常、残余缺血、动脉闭塞或三支血管病变)的患者亚组中观察到了最佳结果,其中心力衰竭患者亚组的死亡率降低了近50%。1996年,β受体阻滞剂的治疗持续时间以及相对于ACE抑制剂的作用尚不清楚。

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